Injection
Sermorelin Injection
A growth hormone-releasing peptide that supports deeper sleep, faster recovery and lean muscle by working with your body's own rhythm.
Starting at $179/mo
Research-stagePeptideGnRHFertility
Kisspeptin
RxPrescription onlyInjected under the skin · Twice a week · 0.1 mg · Research-stage · Peptide · GnRH · Fertility
Starting at $209/mo
A research-stage peptide hormone that signals the brain's GnRH neurons to release LH and FSH. Twice-weekly subcutaneous injections. Evidence is early; this is for patients interested in experimental treatment.
Choose your plan
Real prices from our pharmacy. Longer plans cost less per month and are billed up front. Pause or cancel anytime.
- Works upstream of GnRH—signals the control center of your own hormones
- May help maintain LH/FSH signaling in specific hypogonadal states
- Twice-weekly needle—less frequent than some peptide protocols
Every plan includes
- Personalized, physician-guided plan
- Monthly, 3-month and 6-month plans
- Dispensed by a US-licensed compounding pharmacy
- Unlimited protocol adjustments and messaging
- Ongoing support and check-ins
- Pause or cancel anytime
- Reviewed by our in-house physicians
- Physician-guided care
- Ongoing, expert support
- 100% online
- Free, discreet shipping
What is kisspeptin?
(KISS-pep-tin)
Kisspeptin is a 54-amino-acid peptide hormone discovered in 2003 that acts on the hypothalamus—the brain's hormone control center. It binds to kisspeptin receptors on GnRH neurons, the cells that release gonadotropin-releasing hormone (GnRH), which in turn tells the pituitary to release LH and FSH. These two pituitary hormones drive testosterone and sperm production in men, and estrogen and ovulation in women. Kisspeptin sits upstream of GnRH: it is a signal that says "activate the system." In some types of hypogonadism or low gonadotropin states, kisspeptin may help restart or support the axis. However, the clinical evidence for kisspeptin use in humans is still early—most data come from small trials or case reports, not large randomized studies. It is an experimental therapy.
- How it is taken
- Injected under the skin
- How often
- Twice a week
- Dose range
- 0.1 mg
- Form
- Research-stage · Peptide · GnRH · Fertility
2003
the year kisspeptin was first identified as a key GnRH regulator; human clinical use remains research-stage, with limited published data
Kisspeptin is not FDA-approved for any indication. It is compounded and prescribed off-label at your physician's discretion for research and compassionate use.
How it works,
week by week.
Day 1
A US-licensed physician reviews your hypogonadal state, your history, labs (LH, FSH, testosterone), and goals. You discuss that kisspeptin is experimental and the evidence is limited. Your first supply ships discreetly to your door.
Week 1
Subcutaneous injection of 0.1 mg (10 units) twice weekly. You may feel injection-site reactions (redness, minor swelling) or mild systemic effects (headache, flushing).
Week 2–4
Your physician checks labs (LH, FSH, testosterone) to see if the axis is responding. Not all patients show a response; the evidence suggests response rates vary.
Month 2–3
Your physician reviews your symptom change (energy, mood, sexual function, testicular size if applicable), lab response, and any side effects, and decides whether to continue, adjust, or stop.
Beyond
Kisspeptin therapy is reassessed monthly. Your physician monitors labs and symptoms and reviews the risk-benefit balance with you, as long-term safety data remain limited.
What you may notice,
and when.
LH and FSH may rise
seen in published case reports but not guaranteed in every patient
Energy and mood
some patients report changes; others do not
Fertility potential
kisspeptin's mechanism may support sperm or egg production, but evidence is preliminary
Individual results vary. Benefits reflect what Zepym Health members commonly report to their physician at check-ins; they are not the results of a clinical trial.
Safety first:
what to know before you start.
Important safety information and common side effects
Kisspeptin is an experimental therapy with a limited clinical evidence base in humans. Common effects from small studies include injection-site reactions (redness, swelling, itching), headache, flushing, nausea, and, in men, transient elevations of LH and FSH. Because kisspeptin acts on the hypothalamus and pituitary, it is not prescribed with a pituitary tumor or a hormone-sensitive cancer (prostate, breast). Pregnancy is a contraindication. The long-term effects of kisspeptin therapy in humans are not well characterized—most published experience spans weeks to a few months. Off-label use in hypogonadism rests on physiology and small case series, not large randomized trials. You should be fully informed that kisspeptin is experimental and that you are essentially participating in extended observation. Tell your physician about every medication and supplement you take. Stop and seek care for chest pain, severe headache, vision changes, or signs of pituitary dysfunction (extreme fatigue, weakness, low blood pressure, nausea).
The research behind
kisspeptin.
A hypothalamic peptide that switches on the reproductive hormone axis. It has good human physiology studies in healthy volunteers, but no approved clinical use.
- Healthy adultsLH and FSH rise
In healthy volunteers, intravenous kisspeptin-10 at 10 nmol/kg raised LH and FSH in men and in women during the preovulatory phase, but not in the follicular phase. Groups were four to five people each.
Jayasena et al., J Clin Endocrinol Metab 2011 - Dose in menfrom 0.3 nmol/kg
In healthy men, LH and FSH rose after intravenous kisspeptin-10 at doses as low as 0.3 and 1.0 nmol/kg. The study was short and in volunteers.
Jayasena et al., J Clin Endocrinol Metab 2011 (full text) - Compared with GnRHGnRH more potent
In healthy men, intravenous kisspeptin-10 and kisspeptin-54 gave similar gonadotrophin release, but GnRH was more potent than either at the doses tested.
Abbara et al., Hum Reprod 2015
What the studies found
- Raises LH and FSH in healthy men, and in women during the preovulatory phase, after a single intravenous dose (Jayasena et al., J Clin Endocrinol Metab 2011). These are hormone effects, not clinical outcomes.
- In women with polycystic ovary syndrome, an infusion of kisspeptin-10 raised LH secretion (Hum Reprod 2020).
- In rats, kisspeptin-54 reduced oxidative stress and nerve cell death after brain injury; this animal finding is unproven in people.
These are short physiology studies in volunteers given intravenous doses, not studies of the subcutaneous product sold here. Hormone responses are averages and not predictions of any outcome.
What this does not say
- No approved clinical indication exists for kisspeptin.
- The studies measured hormone release, not fertility, weight or any health outcome.
- A 2015 study found GnRH more potent than either kisspeptin isoform, so kisspeptin's clinical role is unclear.
The research
behind it.
Kisspeptin's role in GnRH signaling is well established in animal models and molecular biology. In humans, kisspeptin signaling defects cause rare forms of hypogonadotropic hypogonadism. Some small studies suggest kisspeptin injections may stimulate LH and FSH release and possibly help restore fertility in selected men.
Clinical evidence in humans is limited. Most published reports involve small numbers of patients with specific diagnoses (hypogonadotropic hypogonadism, Kallmann syndrome). Use in other contexts is anecdotal. Larger, controlled trials are needed to establish efficacy and safety in broader populations.
Getting started
takes a few minutes.
- 1
Connect with a physician
Answer a few questions online and a US-licensed physician reviews your health, history and goals to make sure treatment is right for you. 100% online. No in-person visit required.
- 2
Get your discreet shipment
If approved, your treatment is compounded by a US-licensed, LegitScript-certified pharmacy, inspected for quality, and shipped discreetly to your door.
- 3
Receive continuous support
Start with one goal, then keep building over time. Unlimited physician messaging, easy refills and dose adjustments, all from the Zepym Health app.
Frequently asked questions
Contact supportHow do I use Kisspeptin?
Injected under the skin, twice a week. The starting prescription is 10 units (0.1 mg) each time. Your physician sets your own dose and it is printed on your label.
How much arrives in each shipment?
1 vial at the starting strength, shipped to your door from a licensed US pharmacy.
Is kisspeptin approved by the FDA?
No. Kisspeptin is not FDA-approved for any indication. It is compounded by licensed pharmacies and prescribed off-label at your physician's discretion, typically for research purposes or compassionate use in specific hypogonadal states. You should understand that evidence in humans is limited.
Why is kisspeptin experimental?
Because clinical data in humans are limited. Kisspeptin's role in the hypothalamus is well proven in science, but only small case series and a handful of small trials have tested it in humans with hypogonadism. Larger, controlled studies are needed to know how well it works and what its full safety profile is.
Will it definitely restore my fertility?
Not necessarily. Kisspeptin may help restore LH and FSH signaling in some hypogonadal states, which could support sperm or egg production, but published response rates vary. Some men on kisspeptin show improved sperm counts; others do not. Your physician will monitor labs.
What if kisspeptin doesn't work for me?
Your physician will reassess after a trial period—usually 8–12 weeks. If labs show no LH/FSH response or you have no symptom improvement, your physician may recommend stopping and returning to other options or observation. There is no obligation to continue an ineffective therapy.
Kisspeptin educational content reviewed by our physician
Scott Nass, MD Doctor of Medicine, board-certified in Family Medicine
Charles R. Drew University and David Geffen School of Medicine at UCLA. Family Medicine residency at Ventura County Medical Center.
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References
- 1.The GPR54 gene as a regulator of puberty. N Engl J Med, 2003
- 2.The neuroendocrine physiology of kisspeptin in the human. Rev Endocr Metab Disord, 2007
- 3.Kisspeptin and neurokinin B: roles in reproductive health. Physiol Rev, 2025
Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality. Compounded medications are not FDA-approved brand-name products.