Injection
Sermorelin Injection
A growth hormone-releasing peptide that supports deeper sleep, faster recovery and lean muscle by working with your body's own rhythm.
Starting at $179/mo
Research peptideSleepStress
DSIP
RxPrescription onlyInjected under the skin · 5 days a week · 0.2 mg · Research peptide · Sleep · Stress
Starting at $209/mo
DSIP (delta sleep-inducing peptide): a research peptide studied for sleep quality and stress resilience. Subcutaneous injection, 5 nights per week at bedtime. Early-stage evidence in humans; most support comes from preclinical studies.
Choose your plan
Real prices from our pharmacy. Longer plans cost less per month and are billed up front. Pause or cancel anytime.
- Studied for deep sleep and stress response
- Preclinical evidence strong; human trials limited
- Nightly subcutaneous injection at bedtime
Every plan includes
- Personalized, physician-guided plan
- Monthly, 3-month and 6-month plans
- Dispensed by a US-licensed compounding pharmacy
- Unlimited protocol adjustments and messaging
- Ongoing support and check-ins
- Pause or cancel anytime
- Reviewed by our in-house physicians
- Physician-guided care
- Ongoing, expert support
- 100% online
- Free, discreet shipping
What is DSIP?
(delta sleep-inducing peptide)
DSIP is a peptide discovered in the cerebrospinal fluid of sleeping animals, linked to deep sleep regulation. It is studied off-label for sleep quality and stress. The evidence in animals is solid; human clinical trials are few. It is compounded as a subcutaneous injection, typically 500 mcg to 2 mg, taken at bedtime 5 nights per week.
- How it is taken
- Injected under the skin
- How often
- 5 days a week
- Dose range
- 0.2 mg
- Form
- Research peptide · Sleep · Stress
Preclinical
strong animal evidence; limited human clinical data
DSIP is prescribed off-label at your physician's discretion based on preclinical research and clinical experience. Sleep and stress improvement take 2-4 weeks to notice.
How it works,
week by week.
Day 1
A US-licensed physician reviews your sleep, mood, or cognitive goals, health history, and current medications. Discusses how these early-stage peptides work and the evidence gaps.
Week 1
Start with a subcutaneous injection or intranasal spray at bedtime (or as directed). Most people find the routine comfortable within days.
Weeks 2–4
Sleep quality, mood, or focus may begin to shift. Some notice changes within days; others take 3–4 weeks. Keep a sleep or mood journal.
Month 2
Your physician checks in, reviews your journal, and adjusts dose if needed. Discuss any changes in sleep, mood, energy, or focus.
Beyond
Neuro peptides work best with consistent use. Your physician monitors your response every 4–6 weeks and adjusts as your needs change.
What you may notice,
and when.
Patience required
early-stage therapies take time; effects build over weeks
Improved sleep or mood
tracking with a journal helps you see the changes
Better focus or calm
cognitive clarity or reduced stress as peptides work
Physician partnership
close communication ensures your safety and response
Individual results vary. Benefits reflect what Zepym Health members commonly report to their physician at check-ins; they are not the results of a clinical trial.
Safety first:
what to know before you start.
Important safety information and common side effects
Neuro peptides are prescribed off-label based on preclinical and early clinical evidence. Common mild effects include injection-site reactions, headache, or temporary sleep changes in the first week. DSIP, Semax, and Selank are not prescribed during pregnancy or breastfeeding, or with active psychiatric medication without careful discussion—some combinations require monitoring or dose adjustment. Tell your physician about every medication, supplement, and any history of seizures or psychosis. Stop and seek care for severe headache, agitation, mood changes that interfere with daily life, or signs of allergic reaction.
The research behind
DSIP.
A brain peptide named for its effect on deep sleep. The human sleep studies are old, small and inconsistent.
- Insomnia trialweak, mixed
A double-blind study in 16 chronic insomniacs given 25 nmol/kg intravenously found slightly better sleep efficiency and shorter sleep latency than placebo. The authors judged the effects weak, possibly partly due to a change in the placebo group, and concluded that short-term DSIP is not likely to be of major therapeutic benefit.
Effects of DSIP on sleep of chronic insomniac patients, double-blind study, Neuropsychobiology 1992 - Intravenous studynot significant
In a double-blind crossover study of intravenous DSIP, changes in awakenings and sleep latency were not significantly different from placebo nights. The authors judged the improvement to be of little clinical significance.
Study of DSIP efficacy in improving sleep on short-term administration to chronic insomniacs, PubMed 1987 - Recent trialsnone found
My search found no recent, registered trial of DSIP for sleep. The studies above date from 1984 to 1992.
Literature search of PubMed and Europe PMC
What the studies found
- In a 1992 double-blind study of 16 chronic insomniacs, DSIP improved sleep efficiency and shortened sleep latency compared with placebo, though the authors judged the effects weak (Neuropsychobiology 1992).
- An open 1984 study without a control group reported that most treated patients slept normally afterwards (PubMed 6391926).
- A 1987 crossover study found fewer nighttime awakenings and shorter sleep latency with intravenous DSIP, not significantly different from placebo (PubMed 3583493).
The human studies are from the 1980s and early 1990s. The controlled ones were small: 16 patients in the 1992 double-blind study. The results were mixed and the effects were modest. Compounded and research-grade DSIP has no trial in its own right.
What this does not say
- Human evidence does not show that DSIP improves sleep in a way that matters to patients.
- No trial tested the combinations with BPC-157 or CJC-1295 in the dsip-bpc-157-cjc-1295 blend.
- Long-term safety in people is not documented in the sources reviewed.
The research
behind it.
In animal models, DSIP increases deep (slow-wave) sleep and dampens stress hormone (cortisol) response. It does not appear in urine the next day, suggesting it acts in the CNS and is cleared quickly.
Human clinical trials are limited and older. Your physician explains this gap and follows how you sleep and feel at check-ins. A sleep diary helps track changes.
Getting started
takes a few minutes.
- 1
Connect with a physician
Answer a few questions online and a US-licensed physician reviews your health, history and goals to make sure treatment is right for you. 100% online. No in-person visit required.
- 2
Get your discreet shipment
If approved, your treatment is compounded by a US-licensed, LegitScript-certified pharmacy, inspected for quality, and shipped discreetly to your door.
- 3
Receive continuous support
Start with one goal, then keep building over time. Unlimited physician messaging, easy refills and dose adjustments, all from the Zepym Health app.
Frequently asked questions
Contact supportHow do I use DSIP?
Injected under the skin, 5 days a week, at bedtime. The starting prescription is 20 units (0.2 mg) each time. Your physician sets your own dose and it is printed on your label.
How much arrives in each shipment?
1 vial at the starting strength, shipped to your door from a licensed US pharmacy.
How long until I notice better sleep?
Most people report changes in sleep quality within 2-4 weeks of nightly use. Some notice the effect within days; others take 4-6 weeks. Keep a sleep log to track changes in depth, morning alertness, and how long it takes to fall asleep.
Why are these off-label?
Off-label means not FDA-approved for these uses, but prescribed by physicians based on preclinical research and clinical experience. It is common in medical practice, especially for emerging therapies. Your physician explains what is known and what remains uncertain.
Can I combine these with other medications?
Tell your physician about every medication, especially psychiatric drugs (SSRIs, antipsychotics), stimulants, or sleep aids. Some combinations need careful timing, dose adjustment, or extra monitoring. Do not start or stop any other medications without discussing with your physician.
What if I don't notice a change?
Some people respond quickly; others take 4–8 weeks. Keep a detailed sleep or mood journal to spot subtle changes. If no response after 6–8 weeks, your physician may adjust the dose, try a different peptide, or explore other options.
Are these safe long-term?
Long-term safety data are limited because human use is recent. Your physician monitors you regularly and reassesses the plan every 3–6 months. If any concerning symptoms arise, stop immediately and report them.
DSIP educational content reviewed by our physician
Scott Nass, MD Doctor of Medicine, board-certified in Family Medicine
Charles R. Drew University and David Geffen School of Medicine at UCLA. Family Medicine residency at Ventura County Medical Center.
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References
- 1.Delta sleep-inducing peptide (DSIP): a review of its effects on sleep. Sleep Med Rev, 2003
- 2.Semax: a novel neuropeptide candidate for cognitive enhancement and neuroprotection. Ann NY Acad Sci, 2005
Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality. Compounded medications are not FDA-approved brand-name products.